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Cancer Biomarker Database (Oncology Biomarker Database): A comprehensive diagnostic and prognostic cancer biomarker database (oncology biomarker database) with cancer companion diagnostics biomarker pathway maps. This comprehensive database contains discovery, pre-clinical and clinical cancer biomarkers that were identified or validated using patient samples or animal model or cell based studies. The biomarkers include peripheral blood cancer biomarkers, tumor biomarkers, urinary cancer biomarkers, fecal cancer biomarkers, saliva cancer biomarkers, breath cancer biomarkers, bone marrow cancer biomarkers and CSF cancer biomarkers. Patient/sample details, experimental results/observations, biological and molecular functional analysis, biological process analysis, protein-protein interaction networks of each biomarker are listed in this database. Biomarkers in this database are extracted from patents, research articles and meeting abstracts.
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Biomarker Pathway

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Biomarkers for predicting the efficacy of endocrine therapy consisting of tamoxifen, anastrozole, letrozole or exemestane in breast cancer patients

Biomarkers for predciting the efficacy of anthracycline-based adjuvant chemotherapy with epirubicin in breast cancer patients

Biomarkers for predicting the efficacy of anthracyline treatment in breast cancer patients

Biomarkers for predicting the efficacy of treatment response to pazopanib (Votrient) in renal cell carcinoma patients

Biomarkers associated overall survival in metastatic pancreatic cancer patients treated with ganitumab (GAN; AMG 479) in combination with gemcitabine

Biomarkers associated resistance to cetuximab in metastatic colorectal cancer patients

Biomarkers associated with irinotecan-associated toxicity and drug response in colorectal cancer patients

Biomarkers associated with taxane resistance in breast cancer patients

Biomarkers to predict the efficacy of high-dose methotrexate (MTX) treatment in childhood acute lymphoblastic leukaemia (ALL) patients

Biomarkers for accessing the efficacy of carboplatin, abraxane, and bevacizumab combination therapy in patients with non-small cell lung cancer (NSCLC)

Biomarkers for assessing cardiac effects of doxorubicin (DOX) in children treated for acute lymphoblastic leukemia (ALL)

Biomarkers for determining the therapeutic efficacy of ABL tyrosine kinase inhibitor (imatinib) in chronic myeloid leukemia (CML) patients-1

Biomarkers for determining whether a patient with breast cancer is likely to respond to treatment with trastuzumab, lapatinib or pertuzumab

Biomarkers for identifying or predicting the predisposition to hepatotoxicity or the risk of developing hepatotoxicity and/or elevated ALT or AST in a subject treated with COX-2 selective inhibitor, lumiracoxib

Biomarkers for predciting the efficacy of adjuvant tamoxifen treatment in estrogen receptor (ER)-positive, operable breast cancer patients

Predictive biomarkers for determining whether a patient will benefit from taxane treatment for breast cancer

Biomarkers for prediciting the response to etoposide, gemcitabine, Erlotinib and Cetuximab treatments in non-small cell lung cancer patients

Biomarkers for prediciting the efficacy of bevacizumab treatment in breast cancer patients

Biomarkers for prediciting the efficacy of bevacizumab treatment in colorectal cancer patients

Biomarkers for predicting doxorubicin cardiotoxicity in childhood acute lymphoblastic leukemia (ALL)

Biomarkers for predicting response of a cancer cell tissue to IGF-1R treatment (e.g. IGF1R inhibitor TKI)

Biomarkers for predicting response to endocrine therapy (ET) in ER-alpha positive Stage IV breast cancer

Biomarkers for predicting sunitinib induced cardiac toxicity in metastatic renal cell carcinoma patients

Biomarkers for predicting taxane-induced neuropathy in breast cancer patients

Biomarkers for predicting the benefit from gemcitabine-based chemotherapy after curative-intent surgery in pancreatic adenocarcinoma

Biomarkers for predicting the clinical outcome of anti EGFR therapy (cetuximab or panitumumab) in metastatic colorectal cancer patients

Biomarkers for predicting the clinical outcomes of treatment with motesanib in thyroid cancer patients

Biomarkers for predicting the clinical outcomes of treatment with motesanib in non-small cell lung cancer patients

Biomarkers for predicting the clinical outcomes of treatment with motesanib in breast cancer patients

Biomarkers for predicting the efficacy a combination therapy with bevacizumab (anti-VEGF) plus erlotinib (anti-EGFR) in hepatocellular carcinoma patients

Biomarkers for predicting the efficacy calcitriol treatment in lung cancer patients

Biomarkers for predicting the efficacy of ANA773 tosylate, an oral TLR7-selective agonist, in patients with advanced solid tumors

Biomarkers for predicting poorer survival outcome in head and neck cancer patients treated with gefitinib

Biomarkers for predicting the efficacy of cetuximab treatment in colorectal cancer patients

Biomarkers for predicting the efficacy of dasatinib and docetaxel combination treatment in patients with castration-resistant progressive prostate cancer (CRPC).

Predictive biomarker for risk of endocrine therapy failure in breast cancer patients

Biomarkers for predicting the efficacy of EGFR targeting anti-cancer drugs in non-small cell lung cancer patients

Biomarkers for predicting the efficacy of erlotinib treatment in combination with placebo or R1507, a monoclonal antibody to IGF-1R, for advanced-stage non-small cell lung cancer (NSCLC)

Biomarkers for predicting the efficacy of erlotinib treatment in patients with advanced pancreatic cancer (APC)

Biomarkers for predicting the efficacy of everolimus, an oral mTOR inhibitor, in patients with palliative transitional cell carcinoma (TCC)

Biomarkers for predicting the efficacy of gemcitabine + bevacizumab (GB) combination treatment in advanced or metastatic pancreatic cancer patients

Biomarkers for predicting the efficacy of octreotide LAR treatment in breast cancer patients

Biomarkers for predicting the efficacy of sunitinib treatment in patients with advanced neuroendocrine tumors

Biomarkers for predicting the efficacy of the treatment with a HDAC inhibitor, Vorinostat, in breast cancer patients

Biomarkers for predicting the efficacy of the treatment with a HDAC inhibitor, SAHA (Vorinostat and Zolinza), in cutaneous T-cell lymphoma (CTCL) patients

Biomarkers for the early detection of cardiotoxicity from trastuzumab following anthracycline-based chemotherapy in breast cancer patients

Biomarkers for predicting the efficacy of trastuzumab treatment in metastatic breast cancer patients

Biomarkers for predicting the efficacy of pemetrexed treatment in non-small cell lung cancer patients

Biomarkers for predicting the efficacy of pemetrexed treatment in non-small cell lung cancer patients

Biomarkers for predicting the response to chemoradiotherapy (cisplatin, cetuximab, docetaxel, or erlotinib) in a patient suffering from a head and neck cancer

Biomarkers for predicting the survival in bevacizumab-treated advanced non-small cell lung cancer (NSCLC) patients

Biomarkers for predicting the efficacy of cytarabine/daunorubicin treatment in cytogenetically normal acute myeloid leukemia (CN-AML)

Biomarkers for predicting imatinib resistance in chronic myelogenous leukemia (CML) patients

Biomarkers for predicting the clinical outcome of metastatic colorectal cancer treated with first-line bevacizumab and oxaliplatin-based chemotherapy.

Biomarkers for predicting the efficacy of capecitabine in rectal cancer patients

Predictive biomarkers of ipilimumab on melanoma patients' T-cells

Prognostic biomarkers in patients with metastatic melanoma receiving IL-2 based immunotherapy

Predictive marker of response to antiestrogen therapy in node-neagtive breast cancer

Biomarkers for predicting the efficacy of pemetrexed treatment in patients with nonsquamous non-small cell lung cancer (NSCLC)

Biomarkers for predicting the response to treatment with an epidermal growth factor receptor (EGFR) inhibitor, erlotinib (Tarceva TM), in non-small cell lung cancer (NSCLC) patients-1

Biomarkers for predicting the efficacy of bortezomib treatment in mantle cell lymphoma patients

Biomarkers for predicting the response to treatment with an epidermal growth factor receptor (EGFR) inhibitor, erlotinib (Tarceva TM), in non-small cell lung cancer (NSCLC) patients-2

Biomarkers for predicting the efficacy of taxane treatment in endometrial cancer patients

Biomarkers for predicting the efficacy of bevacizumab treatment in American Joint Committee on Cancer (AJCC) stage III melanoma patients

Biomarkers for predicting the efficacy of lenalidomide or Revimid RTM treatment in patients with non-Hodgkin's lymphoma

Biomarkers for determining the therapeutic efficacy of ABL tyrosine kinase inhibitor (imatinib) in chronic myeloid leukemia patients-2

Biomarkers for predicting overall survival in patients with advanced pancreatic cancer receiving gemcitabine (GEM) monotherapy

Biomarkers associated with paclitaxel-based treatment response and progression-free survival in ovarian cancer patients

Biomarkers for predicting the response of a non-small cell lung cancer patient to treatment with an epidermal growth factor receptor (EGFR) inhibitor, erlotinib (Tarceva TM)

Biomarkers for predicting the efficacy of lenalidomide and pomalidomide in myeloma patients

Biomarkers for predicting the efficacy of COX-2 inhibitor flurbiprofen, indomethacin and other non-steroidal anti-inflammatory drugs (NSAIDs) in cancer patients

Biomarkers for predicting the efficacy of COX-2 inhibitors flurbiprofen, indomethacin and other non-steroidal anti-inflammatory drugs (NSAIDs) in cancer patients

Biomarkers for predicting the efficacy of COX-2 inhibitor in breast cancer patients

Biomarkers for the predicting the efficacy of treatment using EGFR inhibitors geftinib, erlotinib and cetuxima in lung cancer patients

Biomarkers associated with doxorubicin resistance in breast cancer

Biomarkers associated with tamoxifen resistance in breast cancer

Biomarkers associated with TRAIL resistance in Mantle cell lymphoma

Biomarkers associated with the efficacy of treatment using DNA methyltransferase inhibitors (DNMTi), 5-aza-2'-deoxycytidine (5-aza-CdR) or Zebularine, in prostate cancer patients

Biomarkers for predicting the efficacy and safety of bortezomib treatment in multiple myeloma patients

Biomarkers for predicting the efficacy of bortezomib treatment of multiple myeloma patients

Biomarker predicting the response to irinotecan treatment in colon carcinoma patients

Biomarkers for predicting the response to treatment with ChoK alpha Inhibitors in non-small cell lung cancer patients

Biomarkers for predicting the response to treatment with SYK inhibitors in diffuse large B-cell lymphoma (DLBCL) patients

Biomarkers for determining whether a breast cancer patient is likely to benefit from an endocrine treatment (tamoxifen)

Biomarkers for predicting responsiveness of a breast cancer patient to the treatment with anti-VEGF antibody, bevacizumab

Potential biomarkers associated with hypertension in renal cell carcinoma patients treated with VEGF inhibitors

Biomarkers for predicting the response of a metastatic breast cancer patient to treatment with pertuzumab

Biomarkers predictive for response to imatinib therapy in chronic myeloid leukemia (CML) patients -1

Prognostic markers of recombinant human soluble thrombomodulin (rTM) treatment for acute disseminated intravascular coagulation (DIC) by various types of hematologic malignancies

Biomarkers for identifying a melanoma patient who is unresponsive to treatment with a first-generation MEK inhibitor

Biomarkers for identifying a melanoma patient who is likely to benefit from treatment with a second-generation MEK inhibitor

Biomarkers for identifying a melanoma patient having a high risk of relapse during treatment with a first-generation MEK inhibitor

Biomarkers for identifying a melanoma patient who is likely to benefit from treatment with a MEK inhibitor and a RAF inhibitor

Biomarkers for predicting the response to interferon alfa (IFN-alpha) in melanoma patients

Biomarkers for predicting response to rituximab (anti-CD20 antibody) in patients with non-Hodgkin's lymphoma

Biomarkers for predicting the responsiveness of a human follicular CD20 positive non-Hodgkin's lymphoma (NHL) patient to treatment with rituximab

Potential pharmacodynamic biomarkers of dulanermin (rhApo2L/TRAIL) treatment in colorectal cancer patients

Biomarkers for assessing the susceptibility to treatment with histone deacetylase inhibitor (HDACi), belinostat, in colorectal, pancreatic, head and neck, prostate, gastric and esophageal cancer patients

Biomarkers for predicting the efficacy of the treatment with HDAC inhibitors, SAHA (Vorinostat and Zolinza) or Romidepsin (depsipeptide, FK228, and Istodax) or PXD101, in cutaneous T-cell lymphoma (CTCL) patients

Biomarkers associated with the efficacy of a VEGFR tyrosine kinase inhibitor, PTK787/ZK 222584 (PTK/ZK), treatment in colorectal cancer patients

Biomarkers associated with efficacy of bevacizumab plus capecitabine treatment in metastatic breast cancer (MBC) patients

Potential biomarker for predicting celecoxib therapy associated cardiovascular toxicity in colorectal adenoma patients

Biomarkers associated with the prediction of response to bevacizumab treatment in colorectal cancer patients.

Biomarkers associated with the efficacy of Danusertib treatment in solid tumors

Biomarkers associated with response to treatment with aromatase inhibitors in advanced breast cancer patients

Biomarkers associated with the efficacy of VEGFR2 inhibitor therapy in breast cancer patients

Biomarkers predictive for response to imatinib therapy in chronic myeloid leukemia (CML) patients -2

Biomarkers for predicting the efficacy of Bcr-Abl tyrosine kinase specific inhibitor, ST571, treatment in chronic myelogenous leukemia (CML) patients

Biomarkers for predicting the likelihood of a non-small cell lung carcinoma (NSCLC) patient being responsive to TOR kinase inhibitor therapy

Biomarkers for predicting the likelihood of a melanoma patient being responsive to TOR kinase inhibitor therapy

Biomarkers associated with poor prognosis in glioblastoma multiforme (GBM) patients who were treated with TGF-beta inhibitors

Biomarkers associated with predicting the response to or efficacy of treatment with CDK inhibitors (Flavopiridol, Fascaplysin, Roscovitine (Seliciclib ), Olomoucine, DRB) in cancer patients

Potential surrogate endpoint biomarker associated with aromatase inhibitor, anastrozole, treatment in stage I, II breast cancer patients

Biomarkers to identify colorectal cancer patients with K-RAS wild-type tumors who are more likely to benefit from irinotecancetuximab treatment

Biomarkers associated with resistance to anti-epidermal growth factor receptor (EGFR) monoclonal antibody therapy in KRAS wild-type metastatic colorectal cancer (mCRC) patients

Biomarkers for predicting clinical outcome in HER2-positive metastatic breast cancer (mBC) patients treated with lapatinib plus capecitabine

Biomarker associated with treatment response to EGFR inhibitors cetuximab and lapatinib in ovarian cancer patients

Predictive marker associated with EGFR tyrosine kinase inhibitor, gefitinib or lapatinib, treatment in head and neck squamous carcinoma (HNSCC) patients

Biomarkers associated with clinical response to Regorafenib treatment in clear cell renal cell carcinoma patients

Biomarkers for predicting response to Wee1 inhibitor treatment in non-small cell lung cancer (NSCLC) patients

Potential early biomarker to assess the efficacy of combination therapy with ixabepilone plus sunitinib in epithelial ovarian cancer patients

Biomarkers for predicting response to treatment with c-Met inhibitors in prostate cancer and glioblastoma patients

Biomarkers associated with predicting the clinical outcome of dual tyrosine kinase inhibitor, Lapatinib (GW572016), treatment in advanced or metastatic gastric cancer patients

Biomarkers associated with predicting the clinical outcome of sorafenib treatment in hepatocellular carcinoma (HCC) patients

Biomarkers associated with anthracycline-induced cardiotoxicity in childhood acute lymphoblastic leukemia (ALL)

Biomarkers associated with cardiotoxicity in adult acute myeloid leukemia (AML) patients who were treated with conventional and high-dose chemotherapy (HD-CT)

Promising candidate genomic biomarkers of cardiotoxicity associated with doxorubicin therapy in cancer patients

Potential biomarker for predicting the cardioprotective effects of intermittent-dosing of docetaxel (DOC) and adriamycin (ADR) in ADR-DOC combination therapy in cancer patients

Candidate biomarkers for predicting the efficacy of anti-DR5 monoclonal antibody TRA-8 treatment in breast cancer, colon cancer and ovarian cancer patients

Biomarkers for predicting the efficacy of cetuximab alone and in combination with irinotecan-based chemotherapy in colorectal cancer patients

Potential biomarkers for predicting the efficacy of Met inhibitor therapy in gastric cancer patients

Potential biomarkers associated with resistance to taxol-based therapy in ovarian cancer patients

Biomarkers for predicting relapse-free survival in breast cancer patients treated with adjuvant trastuzumab and chemotherapy

Predictive biomarker for response to adjuvant interferon (IFN) therapy in patients with malignant melanoma

Biomarker associated with the efficacy of chemotherapy in combination with interferon-alpha (IFN-alpha) treatment in melanoma patients

Biomarkers for predicting the response to treatment with poly(ADP-ribose) polymerase (PARP) inhibitors in breast cancer and ovarian cancer patients

Biomarkers for predicting responders and non-responders to sunitinib therapy in patients with clear cell renal cell carcinoma

Predictive biomarker of chemotherapy with vinorelbine efficacy in non-small cell lung cancer (NSCLC) patients

Disclaimer: The data contained in the above database is for information purpose only. Biomarkers and related applications reported in patent publications may be covered under specific intellectual property (IP) rights. Please consult with a patent attorney or a legal professional for IP related issues.
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