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Combination therapy for treating polycythemia vera [Patent News]
(Posted 10/05/2011)
(US patent application from Italfarmaco SPA, Italy) A multicentre, randomized, open-label, phase II study testing Givinostat-Hydrochloride-Monohydrate (ITF2357) in combination with N-hydroxyurea (HU) in Polycythemia Vera (PV). Examination of the preliminary data (6 patients) shows that the combined administration of ITF2357 (50 mg/day) and N-hydroxyurea (500 mg/day), to patients suffering from JAK2V617F positive polycythemia vera, produces a significant control of the clinico-hematologic parameters in patients that were refractory to the previous HU monotherapy.
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