ddTargets (Drug Targets / Disease Target Database): This is a unique and comprehensive database on therapeutic drug targets. This database contains drug targets reported in US patents or US/International patent applications and published research articles. The drug targets are also classified according to specific drug types (e.g. small molecule drugs, protein drugs, antibody drugs, siRNA drugs, miRNA drugs etc.) and disease types. The assays and methods used for characterizing each drug targets are listed as well. All the drug targets are linked to various databases such as PubMed (articles), Google Scholar (articles), GeneBank® (nucleotide sequence), UniProt (protein sequence), USPTO (full text patents/patent applications), WO(PCT) (full text international patent applications) and Google patents (full text US patents).

Bioprotocols

Comprehensive database of bioprotocols

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Global Abundant Proteins Affinity Removal (GeneTel Laboratories)

Drug Targets

Drug Types

Disease Targets

New Additions

Drug Target - 5-Hydroxytryptamine receptor 6 (5-HT6 receptor)


US Patent Application: 20090318470
Patent Owner: Wyeth (USA)

		Drug Types
		Small molecule drugs

		Target Diseases Please refer to the patent or patent application for the complete list of target diseases
		Alzheimer's disease, Anorexia, Anxiety, Attention deficit hyperactive disorder, Binge eating disorders, Bulimia, Cognitive disorders, Depression, Disorders resulting from withdrawal from drug abuse, Epilepsy, Feeding disorders, Gastrointestinal disease, Huntington's chorea, Irritable bowel syndrome, Memory disorders, Migraine, Neurodegenerative disease, Pain, Panic attack, Parkinson's disease, Psychoses, Schizophrenia, Schizophrenia, Sleep disorders

		Assays/Methods Used In This Patent Or Patent Application Please refer to the patent or patent application for the complete list of methods used and the details of the protocols
		5HT6 Binding Affinity Pharmacokinetics and CNS Penetration of Compounds were Determined Using HPLC Analysis Microsomal Stability

		Link to USPTO site
		US Patent Application: 20090318470

Drug Target - 5-Hydroxytryptamine receptor 6 (5-HT6 receptor)


US Patent Application: 20090318357
Patent Owner: Tolerx (USA)

		Drug Types
		Antibody drugs, Oligonucleotide drugs, siRNA drugs, Small molecule drugs

		Target Diseases Please refer to the patent or patent application for the complete list of target diseases
		Acute necrotizing hemorrhagic encephalopathy, Allergic asthma, Allergic encephalomyelitis, Alopecia areata, Aplastic anemia, Arthritis, Asthma, Atopic dermatitis, Autoimmune thyroiditis, Autoimmune uveitis, Chronic active hepatitis, Conjunctivitis, Crohn's disease, Crohn's disease, Cutaneous lupus erythematosus, Dermatitis, Diabetes, Drug eruptions, Eczematous dermatitis, Erythema nodosum leprosum, Graves' ophthalmopathy, Idiopathic bilateral progressive sensorineural hearing loss, Idiopathic sprue, Idiopathic thrombocytopenia, Interstitial lung fibrosis, Iritis, Juvenile rheumatoid arthritis, Keratoconjunctivitis, Keratoconjunctivitis sicca secondary to Sjogren's Syndrome, Leprosy reversal reactions, Lichen planus, Multiple sclerosis, Myasthenia gravis, Polychondritis, Primary biliary cirrhosis, Psoriasis, Psoriatic arthritis, Pure red cell anemia, Rheumatoid arthritis, Sarcoidosis, Scleroderma, Sjogren's Syndrome, Stevens-Johnson syndrome, Systemic lupus erythematosis, Ulcerative colitis, Uveitis posterior, Wegener's granulomatosis

		Assays/Methods Used In This Patent Or Patent Application Please refer to the patent or patent application for the complete list of methods used and the details of the protocols
		Proliferation: PI3-Kinase Pathway Identification of Genes Preferentially Expressed in T Effector Cells or T Regulatory Cells Using AffymetrixTM Gene Chips

		Link to USPTO site
		US Patent Application: 20090318357

Drug Target - 5-Hydroxytryptamine receptor 6 (5-HT6 receptor)


US Patent Application: 20090306175
Patent Owner: Abbott Gmbh & Co. (Germany)

		Drug Types
		Small molecule drugs

		Target Diseases Please refer to the patent or patent application for the complete list of target diseases
		Age-related cognitive decline, Alzheimer's disease, Anorexia, Anxiety, Attention deficit disorder, Bipolar disorder, Bulimia, Depression, Drug addiction, Epilepsy, Head Injury, Hyperactivity disorder, Irritable Bowel Syndrome, Migraine, Mild cognitive impairment, Obesity, Parkinson's disease, Schizophrenia, Sleep disorders (including disturbances of circadian rhythm, Spinal or head trauma, Stroke

		Assays/Methods Used In This Patent Or Patent Application Please refer to the patent or patent application for the complete list of methods used and the details of the protocols
		Assay for Testing the Compatibility of Dopamine D3 and 5HT6 Receptor Ligands (Microdialysis Studies) Assay of Microdialysate Acetylcholine Levels

		Link to USPTO site
		US Patent Application: 20090306175

Drug Target - 5-Hydroxytryptamine receptor 6 (5-HT6 receptor)


US Patent Application: 20090306110
Patent Owner: Eli Lilly (USA)

		Drug Types
		Small molecule drugs

		Target Diseases Please refer to the patent or patent application for the complete list of target diseases
		Age-related cognitive disorder, Ahypoglycemic neuronal damage, Amyotrophic lateral sclerosis, Attention deficit hyperactivity disorder, Bipolar disorder, Cardiac arrest, Cerebral ischemia, Cognitive deficits subsequent to cardiac bypass surgery and grafting, Conduct disorder, Convulsions, Dementia, Depression, Epilepsy, Generalized anxiety disorder, Head trauma, Huntington's Chorea, Idiopathic and drug-induced Parkinson's disease, Learning disorders, Mania, Migraine, Mild cognitive impairment, Mood disorder, Multi-infarct dementia, Multiple sclerosis, Narcolepsy, Obsessive compulsive disorder, Panic disorder, Perinatal hypoxia, Schizophrenia, Sleep disorders, Spinal cord trauma, Stroke, Substance withdrawal, Vascular dementia

		Assays/Methods Used In This Patent Or Patent Application Please refer to the patent or patent application for the complete list of methods used and the details of the protocols
		Acquisition in the Radial Maze 8-Arm Radial Maze Acquisition Radial Arm Maze Fear Potentiated Startle Paradigm

		Link to USPTO site
		US Patent Application: 20090306110

Drug Target - 5-Hydroxytryptamine receptor 6 (5-HT6 receptor)


US Patent Application: 20090306092
Patent Owner: H. Lundbeck A/S (Denmark)

		Drug Types
		Small molecule drugs

		Target Diseases Please refer to the patent or patent application for the complete list of target diseases
		Abuse disorders, Bipolar disorder, Brief psychotic disorder, Delusional disorder, Depression, Disease involving a sleep disturbance, Mania, Neuroleptic-induced parkinsonism, Parkinson's disease, Schizoaffective disorders, Schizophrenia, Schizophreniform disorder, Shared psychotic disorder, Substance-induced psychotic disorder

		Assays/Methods Used In This Patent Or Patent Application Please refer to the patent or patent application for the complete list of methods used and the details of the protocols
		In Vitro Antagonistic Effect of Compound I at 5-Ht6 Receptors Rat Disease Model Fox Schizophrenia with Cognitive Deficits

		Link to USPTO site
		US Patent Application: 20090306092

Drug Target - 5-Hydroxytryptamine receptor 6 (5-HT6 receptor)


US Patent Application: 20100022581
Patent Owner: Memory Pharmaceuticals (USA)

		Drug Types
		Small molecule drugs

		Target Diseases Please refer to the patent or patent application for the complete list of target diseases
		Age-related cognitive decline, Alternating constipation, Alzheimer's disease, Anxiety, Attention deficit disorder, Attention deficit hyperactivity disorder, Bulimia, Cardiovascular disease, Constipation, Constipation-predominant irritable bowel syndrome , Creutzfeldt-Jakob disease, Depression, Diarrhea IBS, Disorders associated with spinal trauma or head injury, Epilepsy, Feeding disorders, Gastroesophageal reflux disease, Head trauma, HIV, Huntington's chorea, Huntington's chorea, Irritable bowel syndrome, Manic depression, Migraine, Nocturnal-GERD, Obsessive compulsive disorder, Panic attack, Parkinson's disease, Parkinson's disease, Psychoses, Schizophrenia, Sleep disorders, Withdrawal from drug abuse

		Assays/Methods Used In This Patent Or Patent Application Please refer to the patent or patent application for the complete list of methods used and the details of the protocols
		Assays for determining 5-HT6 receptor activity

		Link to USPTO site
		US Patent Application: 20100022581

Drug Target - 5-Hydroxytryptamine receptor 6 (5-HT6 receptor)


US Patent Application: 20090298841
Patent Owner: Smithkline Beecham (USA)

		Drug Types
		Small molecule drugs

		Target Diseases Please refer to the patent or patent application for the complete list of target diseases
		Alzheimer's disease, Cognitive memory disorder, Obesity

		Assays/Methods Used In This Patent Or Patent Application Please refer to the patent or patent application for the complete list of methods used and the details of the protocols


		Link to USPTO site
		US Patent Application: 20090298841

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