Drug Target - Mitogen-activated protein kinase (MAPK)
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US Patent Application: 20090306182
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Patent Owner: Sirna Therapeutics (USA)
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Drug Types
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siRNA drugs
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Target Diseases
Please refer to the patent or patent application for the complete list of target diseases
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Aberrant Regeneration of Cranial Nerve III,
Absence of the Septum Pellucidum,
Acanthamoeba Keratitis,
Acquired Epileptiform Aphasia,
Acquired Retinoschisis,
Acute Angle Closure Glaucoma,
Acute Bacterial Conjunctivitis,
Acute Disseminated Encephalomyelitis,
Acute inflammation,
Addison's disease,
ADHD,
Adrenoleukodystrophy,
Age related macular degeneration,
Agenesis of the Corpus Callosum,
Agnosia,
Aicardi Syndrome,
AIDS-Neurological Complications,
Alexander's disease,
Allergic conjunctivitis,
Allergic conjunctivitis,
Allergic rhinitis,
Allergic rhinitis,
Allergies,
Alper's syndrome,
Alternating Hemiplegia,
Alzheimer's Disease,
Amaurosis Fugax and Transient Ischemic Attack,
Amyotrophic Lateral Sclerosis,
Anencephaly,
Aneurysm,
Angelman Syndrome,
Angiomatosis,
Angle recession glaucoma,
Anoxia,
Anterior ischemic optic neuropathy,
Anterior Uveitis,
Anterior Uveitis,
Aphasia,
Apraxia,
Arachnoid Cysts,
Arachnoiditis,
Arnold-Chiari Malformation,
Arteriovenous Malformation,
Aspartame,
Asperger's disorder,
Asteroid Hyalosis,
Asthma,
Asthma,
Ataxia,
Ataxia Telangiectasia,
Atherosclerosis,
Atopic dermatitis,
Attention deficit hyperactivity disorder,
Autism,
Autoimmune epilepsy,
Autoimmune hepatitis,
Autonomic Dysfunction,
Autosomal recessive spastic ataxia,
Axenfeld-Rieger Syndrome,
Back Pain,
Bacterial Conjunctivitis,
Bacterial Keratitis,
Bacterial Keratitis,
Barth Syndrome,
Basal Cell Carcinoma,
Batten Disease,
Behcet's Disease,
Bell's Palsy,
Benign Essential Blepharospasm,
Benign Focal Amyotrophy,
Benign Intracranial Hypertension,
Bernhardt-Roth Syndrome,
Binswanger's Disease,
Blepharitis,
Blepharospasm,
Bloch-Sulzberger Syndrome,
Blow-out Fracture,
Brachial Plexus Birth Injuries,
Brachial Plexus Injuries,
Bradbury-Eggleston Syndrome,
Brain and Spinal Tumors,
Brain Aneurysm,
Brain Injury,
Bronchiectasis,
Brown-Sequard Syndrome,
Bulbospinal Muscular Atrophy,
Canaliculitis,
Canavan Disease,
Cancer,
Carotid-Cavernous Sinus Fistula,
Carpal tunnel syndrome,
Causalgia,
Cavernomas,
Cavernous Angioma,
Cavernous Malformation,
Celiac disease,
Celiac disease,
Central Cervical Cord Syndrome,
Central Cord Syndrome,
Central Pain Syndrome,
Cephalic Disorders,
Cerebellar Degeneration,
Cerebellar Hypoplasia,
Cerebral Aneurysm,
Cerebral Arteriosclerosis,
Cerebral Atrophy,
Cerebral Beriberi,
Cerebral Gigantism,
Cerebral Hypoxia,
Cerebral Palsy,
Cerebro-Oculo-Facio-Skeletal Syndrome,
Chalazion,
Charcot-Marie-Tooth disease,
Chemical burns,
Chiari Malformation,
Chlamydia infection,
Chorea,
Choreoacanthocytosis,
Choroidal Melanoma,
Choroidal Rupture,
Chronic cholecystitis,
Chronic Epiphora,
Chronic inflammation,
Chronic inflammatory demyelinating polyneuropathy,
Chronic obstructive pulmonary disease,
Chronic Orthostatic Intolerance,
Chronic Pain,
Chronic pain,
Ciliary-Block Glaucoma,
Coats' Disease,
Cockayne Syndrome Type II,
Coffin Lowry Syndrome,
Coma,
Complex Regional Pain Syndrome,
Congenital Facial Diplegia,
Congenital Myasthenia,
Congenital Myopathy,
Congenital Vascular Cavernous Malformations,
Conjunctival Laceration,
Conjunctival Neoplasms,
Conjunctivitis,
Corneal Abrasion & Recurrent Corneal Erosion,
Corneal Foreign Body,
Corneal Laceration,
Corticobasal Degeneration,
Cranial Arteritis,
Cranial Nerve III Palsy,
Cranial Nerve IV Palsy,
Cranial Nerve VI Palsy,
Cranial Nerve VII Palsy,
Craniosynostosis,
Creutzfeldt-Jakob Disease,
Crohn's disease,
Crystalline Lens Subluxation,
Cumulative Trauma Disorders,
Cushing's disease,
Cystic fibrosis,
Cystoid Macular Edema,
Cytomegalic Inclusion Body Disease,
Cytomegalovirus infection,
Dacryocystitis,
Dancing Eyes-Dancing Feet Syndrome,
Dandy-Walker Syndrome,
Dawson Disease,
De Morsier's Syndrome,
Dejerine-Klumpke Palsy,
Dementia With Lewy Bodies,
Dementia--Multi-Infarct,
Dementia--Subcortical,
Demyelinating Optic Neuropathy (Optic Neuritis),
Dermatomyositis,
Dermatomyositis,
Developmental Dyspraxia,
Devic's Syndrome,
Diabetes,
Diabetic Neuropathy,
Diabetic Retinopathy,
Diffuse Sclerosis,
Dravet's Syndrome,
Duane's Retraction Syndrome,
Dysautonomia,
Dysgraphia,
Dyslexia,
Dysphagia,
Dyspraxia,
Dystonia,
Early Infantile Epileptic Encephalopathy,
Emphysema,
Empty Sella Syndrome,
Encephalitis,
Encephalitis Lethargica,
Encephaloceles,
Encephalopathy,
Encephalotrigeminal Angiomatosis,
Epilepsy,
Episcleritis,
Epithelial Basement Membrane Dystrophy,
Erb's Palsy,
Erb-Duchenne and Dejerine-Klumpke Palsies,
Fabry's Disease,
Fahr's Syndrome,
Fainting,
Familial Dysautonomia,
Familial eosinophilia,
Familial Hemangioma,
Familial Idiopathic Basal Ganglia Calcification,
Familial Spastic Paralysis,
Febrile Seizures ,
Fibromyalgia,
Filamentary Keratitis,
Fisher Syndrome,
Floppy Infant Syndrome,
Friedreich's Ataxia,
Fuchs' Endothelial Dystrophy,
Fungal Keratitis,
Gaucher's Disease,
Generalized epilepsies with febrile seizures and Generalized epilepsies with febrile seizures plus,
Gerstmann's Syndrome,
Gerstmann-Straussler-Scheinker Disease,
Giant Cell Arteritis,
Giant Cell Inclusion Disease,
Giant Papillary Conjunctivitis,
Globoid Cell Leukodystrophy,
Glossopharyngeal Neuralgia,
Glycerol Kinase Deficiency,
Goodpasture's syndrome,
Grave's disease,
Guillain Barre syndrome,
Guillain Barre syndrome,
Hallervorden-Spatz Disease,
Hashimoto's disease,
Head Injury,
Headache,
Hemicrania Continua,
Hemifacial Spasm,
Hemiplegia Alterans,
Hereditary Neuropathies,
Hereditary Spastic Paraplegia,
Heredopathia Atactica Polyneuritiformis,
Herpes simplex infection,
Herpes Simplex Keratitis,
Herpes Zoster,
Herpes Zoster Ophthalmicus,
Herpes Zoster Oticus,
Hirayama Syndrome,
Hollenhorst Plaque,
Holoprosencephaly,
Hordeolum,
Horner's Syndrome,
HTLV-1 Associated Myelopathy,
Huntington's chorea,
Hydranencephaly,
Hydrocephalus,
Hydrocephalus,
Hydromyelia,
Hypercortisolism,
Hypersomnia,
Hypertensive Retinopathy,
Hypertonia,
Hyphema,
Hypotonia,
Hypoxia,
Idiopathic Central Serous Chorioretinopathy,
Immune-Mediated Encephalomyelitis,
Impeded respiration,
Inclusion Body Myositis,
Incontinentia Pigmenti,
Infantile Hypotonia,
Infantile Phytanic Acid Storage Disease,
Infantile Refsum Disease,
Infantile Spasms,
Inflammation,
Inflammation,
Inflammatory bowel disease,
Inflammatory Myopathy,
Inflammatory pelvic disease,
Internuclear Opthalmoplegia,
Intestinal Lipodystrophy,
Intracranial Cysts,
Intracranial Hypertension,
Intracranial Mass Lesions,
Isaac's Syndrome,
Joubert Syndrome,
Keams-Sayre Syndrome,
Kennedy's Disease,
Keratitis Sicca/Dry Eye Syndrome,
Kinsbourne syndrome,
Kleine-Levin syndrome,
Klippel Feil Syndrome,
Klippel-Trenaunay Syndrome,
Kluver-Bucy Syndrome,
Korsakoffs Amnesic Syndrome,
Krabbe Disease,
Kugelberg-Welander Disease,
Kuru,
Lambert-Eaton Myasthenic Syndrome,
Landau-Kleffner Syndrome,
Laryngeal inflammatory disease,
Lateral Femoral Cutaneous Nerve Entrapment,
Lateral Medullary Syndrome,
Lattice Degeneration,
Learning disorders,
Leber's Miliary Aneurysm,
Leigh's syndrome,
Leigh's syndrome,
Lennox-Gastaut Syndrome,
Lens Induced Glaucoma,
Lesch-Nyhan Syndrome,
Leukodystrophy,
Levine-Critchley Syndrome,
Lewy Body Dementia,
Lissencephaly,
Locked-In Syndrome,
Lou Gehrig's Disease,
Lupus,
Lupus erythematosus,
Lupus--Neurological Sequelae,
Lyme Disease--Neurological Complications,
Machado-Joseph Disease,
Macrencephaly,
Macular Degeneration,
Macular Hole,
Megalencephaly,
Melkersson-Rosenthal Syndrome,
Meniere's disease,
Meningitis,
Menkes Disease,
Meralgia Paresthetica,
Metachromatic Leukodystrophy,
Microcephaly,
Migraine,
Miller Fisher Syndrome,
Mini-Strokes,
Mitochondrial Myopathies,
Mobius Syndrome,
Molluscum Contagiosum,
Monomelic Amyotrophy,
Motor neuron disease,
Moyamoya Disease,
Mucolipidoses,
Mucopolysaccharidosis,
Multi-Infarct Dementia,
Multifocal Motor Neuropathy,
Multiple Sclerosis,
Multiple sclerosis,
Multiple System Atrophy,
Multiple System Atrophy with Orthostatic Hypotension,
Muscular Dystrophy,
Myasthenia Gravis,
Myasthenia gravis,
Myasthenia--Congenital,
Myelinoclastic Diffuse Sclerosis,
Myoclonic Encephalopathy of Infants,
Myoclonus,
Myopathy,
Myopathy--Congenital,
Myopathy--Thyrotoxic,
Myotonia,
Myotonia Congenita,
Narcolepsy,
Neovascular Glaucoma,
Neuroacanthocytosis,
Neurodegeneration with Brain Iron Accumulation,
Neurofibromatosis,
Neuroleptic Malignant Syndrome,
Neurological Complications of AIDS,
Neurological Manifestations of Pompe Disease,
Neuromyelitis Optica,
Neuromyotonia,
Neuronal Ceroid Lipofuscinosis,
Neuronal Migration Disorders,
Neuropathy--Hereditary,
Neurosarcoidosis,
Neurotoxicity,
Nevus Cavernosus,
Niemann-Pick's Disease,
O'Sullivan-McLeod Syndrome,
Occipital Neuralgia,
Occult Spinal Dysraphism Sequence,
Ocular inflammation,
Ocular inflammation,
Ohtahara Syndrome,
Olivopontocerebellar Atrophy,
Opsoclonus Myoclonus,
Optic Disc Edema & Papilledema,
Optic Nerve Head Drusen,
Optic Nerve Head Hypoplasia,
Optic pits,
Orbital Cellulitis,
Orthostatic Hypotension,
Overuse Syndrome,
Pain,
Papillophlebitis,
Paraneoplastic Syndromes,
Paresthesia,
Parkinson's disease,
Parmyotonia Congenita,
Paroxysmal Choreoathetosis,
Paroxysmal Hemicrania,
Parry-Romberg,
Pars Planitis,
Pathological Myopia and Posterior Staphyloma,
Pediculosis and Pthiriasis,
Pediculosis and Pthiriasis,
Pelizaeus-Merzbacher Disease,
Pena Shokeir II Syndrome,
Perineural Cysts,
Periodic paralysis,
Peripheral Neuropathy,
Periventricular Leukomalacia,
Pernicious anemia,
Persistent Vegetative State,
Persistent Vegetative State,
Pervasive Developmental Disorders,
Phlyctenulosis,
Phytanic Acid Storage Disease,
Pick's Disease,
Pigment Dispersion Syndrome & Pigmentary Glaucoma,
Pigment Dispersion Syndrome & Pigmentary Glaucoma,
Pingueculitis,
Piriformis Syndrome,
Pituitary Adenoma,
Pituitary Tumors,
Pneumoconiosis,
Polymyositis/dermatomyositis,
Pompe Disease,
Porencephaly,
Post-Polio Syndrome,
Posterior Vitreous Detachment,
Postherpetic Neuralgia,
Postinfectious Encephalomyelitis,
Postural Hypotension,
Postural Orthostatic Tachycardia Syndrome,
Postural Tachycardia Syndrome,
Preseptal Cellulitis,
Presumed Ocular Histoplasmosis Syndrome,
Prevention of allograft rejection),
Primary biliary sclerosis,
Primary Lateral Sclerosis,
Primary Open Angle Glaucoma,
Primary Open-Angle Glaucoma,
Prion Diseases,
Progressive Hemifacial Atrophy,
Progressive Locomotor Ataxia,
Progressive Multifocal Leukoencephalopathy,
Progressive Sclerosing Poliodystrophy,
Progressive Supranuclear Palsy,
Pseudoexfoliation Syndrome and Pseudoexfoliative Glaucoma,
Pseudoexfoliation Syndrome and Pseudoexfoliative Glaucoma,
Pseudotumor Cerebri,
Pseudotumor Cerebri,
Pterygium,
Pulmonary hypertension,
Pulmonary vasoconstriction,
Pulmonary vasoconstriction,
Pyridoxine Dependent and Pyridoxine Responsive Siezure Disorders,
Ramsay Hunt Syndrome Type I,
Ramsay Hunt Syndrome Type II,
Rasmussen's Encephalitis and other autoimmune epilepsies,
Rasmussen's Encephalitis and other autoimmune epilepsies,
Reflex Sympathetic Dystrophy Syndrome,
Refsum Disease,
Refsum Disease--Infantile,
Reiter's syndrome,
Repetitive Motion Disorders,
Repetitive Stress Injuries,
Respiratory diseases,
Respiratory distress syndrome,
Restenosis,
Restless legs syndrome.,
Retinal Artery Occlusion,
Retinal Detachment,
Retinal Macroaneursym,
Retinal Pigment Epithelium Detachment,
Retinal Vein Occlusion,
Retinal Vein Occlusion,
Retinitis Pigmentosa,
Retrobulbar Optic Neuritis,
Retrovirus-Associated Myelopathy,
Rett Syndrome,
Reye's Syndrome,
Rheumatoid arthritis,
Rheumatoid arthritis,
Riley-Day Syndrome,
Sacral Nerve Root Cysts,
Saint Vitus Dance,
Salivary Gland Disease,
Salzmann's Nodular Degeneration,
Sandhoff Disease,
Schilder's Disease,
Schizencephaly,
Scleritis,
Scleroderma,
Sclerosing cholangitis,
Sclerosis,
Seizure Disorders,
Senile Entropion,
Septic shock,
Septo-Optic Dysplasia,
Severe Myoclonic Epilepsy of Infancy,
Shaken Baby Syndrome,
Shingles,
Shy-Drager Syndrome,
Silicosis,
Sinusitis,
Sjogren's syndrome,
Sjogren's Syndrome,
Sleep Apnea,
Sleeping Sickness,
Soto's Syndrome,
Spasticity,
Spina Bifida,
Spinal Cord Infarction,
Spinal Cord Injury,
Spinal Cord Tumors,
Spinal Muscular Atrophy,
Spinocerebellar Atrophy,
Squamous Cell Carcinoma,
Steele-Richardson-Olszewski Syndrome,
Sterile Corneal Infiltrates,
Stiff-Person Syndrome,
Striatonigral Degeneration,
Stroke,
Sturge-Weber Syndrome,
Subacute Sclerosing Panencephalitis,
Subcortical Arteriosclerotic Encephalopathy,
SUNCT Headache,
Superior Limbic Keratoconjunctivitis (SLK of Theodore),
Swallowing Disorders,
Sydenham's chorea,
Syncope,
Syphilitic Spinal Sclerosis,
Syringohydromyelia,
Syringomyelia,
Systemic lupus erythematosus,
Systemic lupus erythematosus,
Tabes Dorsalis,
Tardive Dyskinesia,
Tarlov Cysts,
Tay-Sachs Disease,
Temporal Arteritis,
Terrien's Marginal Degeneration,
Tethered Spinal Cord Syndrome,
Thomsen Disease,
Thoracic Outlet Syndrome,
Thygeson's Superficial Punctate Keratopathy,
Thyrotoxic Myopathy,
Tic Douloureux,
Todd's Paralysis,
Tonic Pupil,
Tourette's syndrome,
Toxic Conjunctivitis,
Toxic/Nutritional Optic Neuropathy,
Toxocariasis (Ocular Larva Migrans),
Toxoplasmosis,
Tractional Retinal Tears,
Transient ischemic attack,
Transmissible Spongiform Encephalopathies,
Transplantation rejection,
Transverse Myelitis,
Traumatic Brain Injury,
Tremor,
Trigeminal Neuralgia,
Tropical Spastic Paraparesis,
Tuberculosis,
Tuberous Sclerosis,
Ulcerative colitis,
Uveitic Glaucoma & Glaucomatocyclitic Crisis,
Vascular Erectile Tumor,
Vasculitis including Temporal Arteritis,
Vernal Conjunctivitis,
Verruca and Papilloma,
Viral Conjunctivitis,
Von Economo's Disease,
Von Hippel-Lindau disease,
Von Recklinghausen's Disease,
Wallenberg's Syndrome,
Wegener's granulomatosis,
Werdnig-Hoffman Disease,
Wernicke-Korsakoff Syndrome,
West Syndrome,
Whipple's Disease,
Williams Syndrome,
Wilson's Disease,
X-Linked Spinal and Bulbar Muscular Atrophy,
Zellweger Syndrome
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Assays/Methods Used In This Patent Or Patent Application
Please refer to the patent or patent application for the complete list of methods used and the details of the protocols
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- MAP Kinase Targeted siNA Design
- Chemical Synthesis and Purification of siNA
- Selection of siNA Molecule Target Sites in a RNA
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Link to USPTO site
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US Patent Application: 20090306182
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